GHK-Cu is a naturally occurring copper complex that was first identified in human plasma, but has recently been found in multiple locations such as saliva and urine. Copper peptides are small, naturally occurring protein fragments that have high affinity for copper ions, which are critical to normal body function. GHK-Cu has a variety of roles in the human body including, promoting activation of wound healing, attracting immune cells, having anti-oxidant and anti-inflammatory effects, stimulating collagen and glycosaminoglycan synthesis in skin fibroblasts, and promoting blood vessel growth.
Evidence has shown that it acts as a feedback signal that is generated after tissue injury. It seems to act as a potent protector of tissue and it is an anti-inflammatory agent that controls the oxidative damage that occurs after tissue injury. Further, it then plays a big role in signaling tissue remodeling which removes damaged/scarred tissue and generates new, healthy tissue.
These positive effects decline with age because the concentration of GHK-Cu in the body decreases with age. Thus, there is an increase in inflammation, cancerous activity, and tissue destruction. In plasma, the level of GHK-Cu is about 200 ng/ml at age 20. By the age of 60, the level drops to 80 ng/ml.
May use injectable and topically.
Some of the potential benefits of GHK-Cu are:
- Tighten loose skin and reverse thinning of aged skin
- Repair protective skin barrier proteins
- Improve skin firmness, elasticity, and clarity
- Reduce fine lines, depth of wrinkles, and improve structure of aged skin
- Smooth rough skin
- Reduce photodamage, mottled hyperpigmentation, skin spots and lesions
- Improve overall skin appearance
- Stimulate wound healing
- Protect skin cells from UV radiation
- Reduce inflammation and free radical damage
- Increase hair growth and thickness, enlarge hair follicle size
GHK-Cu Aesthetic Effects
GHK stimulates both synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity of both metalloproteinases and their inhibitors. It stimulates collagen, dermatan sulfate, chondroitin sulfate, and the small proteoglycan, decorin. It also restores replicative vitality to fibroblasts after radiation therapy. The molecule attracts immune and endothelial cells to the site of an injury. It accelerates wound healing of the skin, hair follicles, gastrointestinal tract, and boney tissue. In cosmetic products, it has been found to tighten loose skin and improve elasticity, skin density, and firmness, reduce fine lines and wrinkles, reduce photodamage, and hyperpigmentation, and increase keratinocyte proliferation.